Evidence Card: NCBI:LOC105317003
Simulated demo evidence: This card does not describe real-study findings.
Status: Association evidence only; not a validated biomarker.
- Candidate score: 0.5803
- Ranking category: Multi-omics convergence candidate
- Species context: Crassostrea gigas
- Ortholog/reference context: ORTHO_SHELL_C
- Supporting studies: CGIG_HEAT_RNASEQ_001, CGIG_LARVAL_PROCESSED_001, CGIG_OA_METHYL_001
- Assay types represented: gene, genomic_region
- Phenotype/stressor/tissue contexts: acidification_tolerance / ocean_acidification_pH / mantle; larval_viability / multi_stressor_exposure / larvae; thermal_tolerance / temperature / gill
- Direction of association: down: 2, hypermethylated: 1
- Identifier mapping confidence: one-to-one ortholog
- Limitations: nearest_gene_annotation; none; suggestive_phenotype
- Effects without usable uncertainty or with exploratory inference (not pooled in meta-analysis): none
Effect Summary
| study_id | feature_type | effect_size | standard_error | adjusted_p_value |
|---|---|---|---|---|
| CGIG_HEAT_RNASEQ_001 | gene | -0.7 | 0.25 | 0.06 |
| CGIG_LARVAL_PROCESSED_001 | gene | -1.05 | 0.41 | 0.07 |
| CGIG_OA_METHYL_001 | genomic_region | 0.18 | 0.06 | 0.03 |
Recommended Next Validation Step
Prioritize independent biological replication with matched phenotype definitions and targeted validation in the relevant tissue and life stage.