Evidence Card: NCBI:LOC105317004
Simulated demo evidence: This card does not describe real-study findings.
Status: Association evidence only; not a validated biomarker.
- Candidate score: 0.5807
- Ranking category: Multi-omics convergence candidate
- Species context: Crassostrea gigas
- Ortholog/reference context: ORTHO_METAB_D
- Supporting studies: CGIG_HEAT_RNASEQ_002, CGIG_OA_METHYL_001, CGIG_PATH_PROTEO_001
- Assay types represented: gene, genomic_region, protein
- Phenotype/stressor/tissue contexts: acidification_tolerance / ocean_acidification_pH / mantle; disease_resistance / pathogen_challenge / hemolymph; survival / temperature / mantle
- Direction of association: hypomethylated: 1, lower: 1, up: 1
- Identifier mapping confidence: many-to-one ortholog, one-to-many ortholog
- Limitations: none; processed_only
- Effects without usable uncertainty or with exploratory inference (not pooled in meta-analysis): none
Effect Summary
| study_id | feature_type | effect_size | standard_error | adjusted_p_value |
|---|---|---|---|---|
| CGIG_HEAT_RNASEQ_002 | gene | 0.8 | 0.34 | 0.07 |
| CGIG_OA_METHYL_001 | genomic_region | -0.12 | 0.05 | 0.1 |
| CGIG_PATH_PROTEO_001 | protein | -0.6 | 0.33 | 0.11 |
Recommended Next Validation Step
Prioritize independent biological replication with matched phenotype definitions and targeted validation in the relevant tissue and life stage.